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Vaccine Weekly

Susan Hasty, Publisher

Table of Contents . . . February 9th, 2005

Non-Subscriber - Summaries Only

Related Areas: Other Issues in Vaccine Weekly | Other Publications

Anthrax Vaccine - Anthrax capsule vaccine protects against experimental infection

Anthrax Vaccines - Reports advance knowledge in anthrax vaccines research

Cancer Vaccine - Acid-degradable particles for protein-based vaccines enhances survival rate

HIV/AIDS Vaccine - Adjuvant for mucosal immunity to HIV-1 gp120 in nonhuman primates developed

SARS Vaccine - SARS-CoV vaccine elicits antibodies that block virus entry

SARS Vaccines - New findings in SARS vaccines described

Vaccine Development - Lipopeptide epitopes trigger Th1-dependent protective immunity

Anthrax Vaccine - Anthrax lethal toxin causes multisystem destruction

Antimicrobials - Evolution of equine infection control programs reviewed

Autoimmune Disease - Healthy blood donors have high levels of neutralizing IL-6 autoantibodies

Bioterrorism - Second-generation smallpox vaccine for biological defense described

Bioterrorism - Smallpox containment updated

Bordetella Vaccine -  Bordetella pertactin gene variants in swine vaccines analyzed

Bovine Leukemia Virus - Retroviral structural gene vector protects against bovine leukemia virus

Breast Cancer - Chemotherapeutic drug gets 2 new European approvals as breast cancer treatment

Breast Cancer - Gene vaccine protects mice against development of HER2/neu breast cancer

Breast Cancer - Progesterone receptor by immunohistochemistry predicts breast cancer outcome

Business Update - Biotechnology company clarifies 3:1 split timing, announces stem cell initiative

Business Update - Company updates cancer and HIV clinical-development programs

Business Update - Liposome vaccine to be company's focus in 2005

Business Update - Pharmaceutical company updates 2005 first half milestones

Business Update - Rapid flow through diagnostic producer receives orders from Prestige Group

Cancer Therapy - Cancer vaccines: A two-pronged attack?

Cancer Vaccine - Anti-CD137 antibody augments antitumor efficacy of dendritic cell vaccines

Cancer Vaccine - Human vaccinia-related kinase 1 induces stabilization and accumulation of p53

Cancer Vaccine - Immunological prevention of multigene cancer syndrome

Cancer Vaccine - Progress in developing tumor cell vaccine reviewed

Cancer Vaccine - Self-reactive T cell receptor-reactive CD8+ T cells inhibit lymphoma growth

Cancer Vaccines - Recent findings illuminate research in cancer vaccines

Cancer Vaccines - Researchers' data advance cancer vaccines research

Cervical Dysplasia - Vaccine to treat cervical dysplasia licensed to Cancer Research Technology

Chagas Disease - Antigens of Trypanosoma cruzi stimulate cellular immune response in mice

Clinical Trails - Biopharma company reports encouraging Altastaph phase I/II results in adults

Collaborations - Agreements completed with Children's Hospital & Research Center at Oakland

Collaborations - Sanofi-aventis signs oncology collaboration with biopharmaceutical company

Cystic Fibrosis - Amiloride analogs as therapy for cystic fibrosis lung disease evaluated

Cytomegalovirus Vaccine - Human T cells specific for glycoproteins recognize cytomegalovirus sequences

Cytomegalovirus Vaccine - Murine cytomegalovirus gene encodes gp24 virion glycoprotein

Diagnostics - IFN-gamma production assay after M. tuberculosis infection evaluated

Diagnostics - Researchers provide details of new studies and findings in the area of diagnostics

Ebola Virus Vaccine - Antibodies produced against envelope glycoprotein GP of Ebola virus

Encephalomyelitis - Reports add new data to encephalomyelitis research

Fetal Health - Prevention and management of RhD isoimmunization reviewed

Finance - STD-focused diagnostics company issues $2 million note to Marr

HIV/AIDS Drug Development - Pharma company files three antiretrovirals with the U.S. FDA

HIV/AIDS Education - Rights to documentary 'The Origins of AIDS' acquired by filmmaker Robert Redford

HIV/AIDS Transmission - HIV T-lymphocyte responses in exposed uninfected sex workers studied

HIV/AIDS Treatment - Pharmaceutical company prepares for late-stage clinical trials for HIV treatment

HIV/AIDS Vaccine - Cassette-based presentation of SIV epitopes with gas vesicles is feasible

HIV/AIDS Vaccine - Factors limiting immunogenicity of HIV gp120 envelope glycoproteins outlined

HIV/AIDS Vaccine - Intranasal HIV-1 peptide elicits long-term HIV neutralizing immunity

HIV/AIDS Vaccines - Findings advance knowledge in HIV/AIDS vaccines research

Haemophilus Vaccines - Studies add new findings to haemophilus vaccines body of knowledge

Helminth Vaccine - Dendritic cell maturation by Nippostrongylus proteins drives immune response

Immunization - Fusogenic liposomal vector is a potent gene vaccine delivery vehicle

Immunology - Antigen concentrates in small number of antigen presenting cells

Immunology - Generation and maintenance of immunological memory reviewed

Immunology - Immunity to extracellular domain of Nogo-A modulates encephalomyelitis

Immunology - Kinetics and clonality of immunological memory in humans reviewed

Immunology - Reports add new data to immunology research

Immunology - Substitutions in mutant hepatitis B virus surface antigens are immunogenic

Immunology - Transporter for antigen processing preselection of peptides binding evaluated

Immunotherapy - CD4+ CD25+ T cells help prevent severe arthritis in Lyme disease

Immunotherapy - Immune regulation via CD1d-dependent NKT cells reviewed

Infectious Disease Research - Company awarded $24 million to study genetics of infectious disease and vaccines

Influenza - Biotechnology company receives U.S. FDA clearance for Fluviral clinical testing

Influenza Vaccine - Attenuated influenza vaccine induces cross-reactive antibody responses

Influenza Vaccine - Data from Vaxin's first flu vaccine clinical trial reported

Influenza Vaccine - Maine lifts restrictions on use of flu vaccine

Influenza Vaccine - Nearly 10,000 doses of flu vaccine available statewide in Arkansas

Influenza Vaccine - New Mexico lifts order restricting flu vaccine

Influenza Vaccine - Restriction on flu shots lifted in Oklahoma

Influenza Vaccine - Vaccine maker takes first steps toward vaccine against deadly flu strain

Influenza Virus - Transmissibility of 1918 pandemic influenza reviewed

Lymphocytic Choriomeningitis Virus - Antigen-independent T cells do not develop during chronic viral infection

Lymphocytic Choriomeningitis Virus - CCR7 not required for maintaining antiviral memory

Lymphoma - Stem cell transplants viable option for patients suffering from lymphoma and HIV

Malaria - Recent findings in malaria provide new insights

Malaria Vaccines - Researchers detail new studies and findings in the area of malaria vaccines

Melanoma Vaccine - Mouse MAGE-derived H-2Kb-restricted CTL epitopes characterized

Multiple Sclerosis - Researchers' work adds to multiple sclerosis body of knowledge

Myasthenia Gravis - Studies describe new findings in myasthenia gravis research

Myocarditis - Immunoglobulins suppress autoimmune myocarditis in immunodeficient mice

Neuroscience - A-beta specific antibody reduces beta-amyloid in Alzheimer model

Pancreatic Cancer - New findings in the area of pancreatic cancer detailed

Patents - Biotechnology company files citations relevant to Benitec patent

Personnel - Biothrax maker names Dr. Steven Chatfield named chief scientific officer

Pertussis - After whooping cough outbreak, researchers plan immunization study

Philanthropy - Pharmaceutical company reports on its response to tsunami

Philanthropy - Repertory theatre presents "Foreign Aids" to benefit AIDS organizations

Plague - Phase I trial announced for recombinant injectable plague vaccine candidate

Pneumococcal Vaccine - Antibodies elicited by conjugates of pneumococcal polysaccharide compared

Pneumococcal Vaccine - Weight-based antibody units assigned for antipneumococcal reference serum

Polio Vaccine - Poliovirus revaccination elicits long-term immunity in stem cell recipients

Poxvirus Vaccine - Cellular source of poxviral N1R/p28 gene family identified

Preventive Medicine - Clinical pharmacy travel medicine services reviewed

Product Licensing - Therapeutics company licenses DISC-HSV and DISC-GM-CSF vector platforms

Public Health - Public vaccination policies for containing anthrax outbreak outlined

Receptor Studies - Polymeric Ig binding fragment of polymeric Ig receptor characterized

Rheumatoid Arthritis - Collagen-specific T cells tracked in collagen-induced arthritis

Rheumatoid Arthritis - Inhibition of fractalkine ameliorates murine collagen-induced arthritis

Ricin - Companies enter into a development and manufacturing process agreement for RiVax

Rotavirus - Global launch with Rotarix starts in Mexico

Rotavirus Vaccine - Antibody responses in calves and piglets infected with rotavirus reported

SARS Vaccine - Replication of SARS coronavirus in monkey respiratory tract investigated

SARS Vaccines - New findings in the area of SARS vaccines detailed

Smallpox Vaccine - Voluntary smallpox vaccination requires information about attack likelihood

Sports Medicine - Athletes should be vaccinated against hepatitis B virus infection

Streptococcus Vaccine - Antigenic determinants of alpha-like proteins of Streptococcus examined

Streptococcus Vaccine - Immunogenic proteins released from Streptococcus agalactiae identified

Syphilis - Diagnostics company adds syphilis test to its inventory

Tuberculosis Vaccine - Vgamma T cell stimulation optimizes TB vaccine-induced CD8 T cell immunity

Tularemia Vaccine - IglC expression needed for apoptosis in macrophages by Francisella

Type 2 Diabetes - Data shows potential of arimoclomol as a therapeutic for type 2 diabetes

Vaccine Delivery - Antigen-specific B lymphocytes regulate delivery of therapeutic proteins

Vaccine Development - Combination vaccines immunize adults against typhoid and hepatitis A

Vaccine Development - Combined vaccines synergize to resist cancer growth

Vaccine Efficacy - Contraction phase of viral T cells unaffected by pan-caspase inhibitor

Vaccine Efficacy - Dietary ribonucleotides affect infant humoral immune status

Vaccine Efficacy - Statistical tests to determine vaccine efficacy evaluated

Vaccine Safety - Child with itching nodule receives aluminum-containing vaccine safely

Vaccines Development - Researchers describe findings in vaccines development studies

Vaccinia Virus - Protein interactions among vaccinia virus transcription factors described

Vector Development - DNA sequences maintain stability during plasmid processing

Virology - Antiviral immunity requires Toll-like receptor signaling

Virology - Apathogenic hepatitis G vaccine might benefit patients infected with HIV

Virology - Liposomal peptide vaccine primes T cells against cells bearing HCV protein

West Nile Virus Vaccine - Attenuated West Nile prototype virus protects against deadly NY99 strain

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