Cancer Vaccine

Gangliosides and glycoproteins are receptors for the anticancer drug rViscumin

Published in Vaccine Weekly, February 16th, 2005

Tumor-associated CD75s gangliosides and CD75s-bearing glycoproteins with Neu5Ac alpha 2-6Gal beta 1-4GlcNAc residues are receptors for the anticancer drug rViscumin.

"The anticancer drug rViscumin, currently under clinical development, has been shown in previous studies to be a sialic acid specific ribosome inactivating protein (RIP). Comparative binding assays with the CD75s-specific monoclonal antibodies HB6 and J3-89 revealed rViscumin to be a CD75s-specific RIP due to identical binding characteristics toward CD75s gangliosides. The receptor gangliosides are IV⁶nLc4Cer, VI⁶nLc6Cer, and the newly characterized ganglioside VIII⁶nLc8Cer,...

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Source: Vaccine Weekly (2005-02-16)

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