Pertussis Vaccine

Antigenic variation linked to B. pertussis electrophoresis profiles

Published in Vaccine Weekly, March 9th, 2005

The correlation between antigenic variation and pulsed-field gel electrophoresis profiles of Bordetella pertussis isolates in Japan suggests antigenic divergence.

According to published research from Japan, "Antigenic divergence has been found between Bordetella pertussis vaccine strains and circulating strains in several countries. In the present study, we analyzed B. pertussis isolates collected in Japan from 1988 to 2001 using pulsed-field gel electrophoresis (PFGE) and sequencing of two virulence-associated proteins. The 107 isolates were classified into three major groups by PFGE analysis; 87 (81%) were type A, 19 (18%) were type B, and 1 (1%)...

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Source: Vaccine Weekly (2005-03-09)

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