Immunology

Secrets of HIV unbound

Published in Vaccine Weekly, March 16th, 2005

Acquired immunodeficiency syndrome (AIDS) in humans and monkeys is caused by the human immunodeficiency virus (HIV) and simian immunodeficiency virus (SIV), respectively.

Both viruses express a protein called gp120, which binds to immune cells expressing another protein, called CD4, on their surface. Binding of gp120 to CD4 causes the virus to infect cells. The structure of gp120 bound to CD4 has been known since 1998; however, the unbound form - which is important for the design of therapeutics and vaccines - has eluded researchers for decades.

In Nature, Stephen Harrison and his colleagues at Harvard Medical School, in a technical tour de...

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Source: Vaccine Weekly (2005-03-16)

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