Published in Vaccine Weekly, March 23rd, 2005
"Streptococcus pneumoniae causes considerable morbidity and mortality worldwide. The need for a cheap and effective pneumococcal vaccine has necessitated the evaluation of common virulence-associated proteins as potential vaccine antigens. PiuA and PiaA are the lipoprotein components of two pneumococcal iron ABC transporters," investigators in England report.
"Here, we show that patients with culture confirmed pneumococcal septicemia have elevated levels of antibody to PiuA and PiaA...
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