Diabetes Genomics and Genetics
Adenovirus transgenes expressed in beta cells prevent type 1 diabetes
Published in Vaccine Weekly, March 30th, 2005
According to recent research from the United States, "The incidence of type 1 diabetes (T1D) is decreased in nonobese diabetic mice expressing the complete cassette of adenovirus early region 3 (E3) immunomodulating genes in pancreatic beta cells. Embedded among the anti-apoptotic E3 genes is one encoding an adenovirus death protein (ADP), which contributes to release of virion particles by promoting cell lysis. Because removal of this pro-apoptotic protein might have further enhanced the ability of E3 proteins to prevent T1D, an ADP-inactivated E3...
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Source: Vaccine Weekly (2005-03-30)
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