Polio Vaccine

Immunization schedules affect excretion of polio vaccine strains

Published in Vaccine Weekly, March 30th, 2005

Immunization schedules affect the excretion and reversion of oral polio vaccine strains.

"Excretion of live oral polio vaccine and molecular markers of increased virulence in the viruses isolated were examined in children who were either previously immunized with inactivated or live vaccine or were unimmunized. There appeared to be some effect of previous immunization with either live or killed vaccine at the second dose of live vaccine. Where an effect was seen, it took the form of reduced rates of excretion, shorter time periods of excretion, and more rapid and complete reversion of the excreted virus," researchers in England report.

"The data are...

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Source: Vaccine Weekly (2005-03-30)

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