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Vaccine Weekly

Susan Hasty, Publisher

Table of Contents . . . April 6th, 2005

Non-Subscriber - Summaries Only

Related Areas: Other Issues in Vaccine Weekly | Other Publications

Borna Disease - Orf virus protects against Borna disease virus infection of the brain

Cancer Vaccine - Imatinib mesylate overcomes tumor-induced CD4+ T-cell tolerance

Cytomegalovirus Vaccine - Cytomegalovirus DNA vaccine protects against murine cytomegalovirus challenge

HIV/AIDS Vaccine - HIV preclinical interventions in nonhuman primates investigated

HIV/AIDS Vaccine - Rhabdoviral prime-boost induces strong anti-HIV immune responses

Alzheimer Disease - Cerebral hemorrhage dependent on antibody recognition of amyloid beta

Anthrax Vaccines - Reports advance knowledge in anthrax vaccines research

Asthma Vaccine - Vaccine protects against B. pertussis exacerbation of allergic asthma

Avian Influenza - Investigational pandemic influenza vaccine for NIAID clinical trials delivered

Awards - GlaxoSmithKline CEO Jean-Pierre Garnier gets Global Business Leadership award

Biotechnology - Jonathan Pockson named SVP and CFO

Cancer Vaccines - Studies describe new findings in cancer vaccines research

Bioterrorism - U.S. NIAID $15 million contract awarded to develop three monoclonal antibodies

Bovine Viral Diarrhea Virus - Genome analysis of live bovine viral diarrhea virus vaccine conducted

Breast Cancer Therapy - Arg-482 not essential for transporting antibiotics, bile acids, and sterols

Breast Cancer Vaccine - DNA vaccine inhibits breast cancer in mice through induction of autoimmunity

Business & Finance - Anti-infectives-focused drug company reports fourth quarter 2004 results

Business & Finance - Biopharma company announces financial results

Immunology - Studies describe new findings in immunology research

Business Update - Medical services company extends distribution over 10 Chinese provinces

Business Update - Pharma companies enter agreement for deorphanization of a series of proteases

Business Update - Pharmaceutical company updates Novartis peptide deformylase inhibitor program

Cancer Therapy - Patient enrollment almost complete in study of vaccine for prostate cancer

Cancer Vaccine - Blockade of B7-H1 and PD-1 by antibodies potentiates cancer immunity

Cancer Vaccine - DNA vaccination against tumors reviewed

Malaria Vaccines - Researchers describe findings in malaria vaccines studies

Cancer Vaccine - DNA vaccine encoding genetic fusion of CEA and GM-CSF developed

Cancer Vaccine - Impact of p53-based immunization on chemically-induced tumors investigated

Cancer Vaccine - Role of exosomes in cancer-associated T-cell signaling defects investigated

Cancer Vaccines - Reports describe recent advances in cancer vaccines research

Cervical Cancer - Most women willing to accept vaccine for self and children

Tuberculosis Vaccines - Recent findings in tuberculosis vaccines described

Chagas Disease Vaccine - Oral immunization with Phytomonas serpens protects against Trypanosoma

Chlamydia Vaccine - Immunology of Chlamydia infection aids Chlamydia vaccine design

Clinical Trials - Enrollment of phase 2 clinical trial of antibody for treatment of HIV complete

Collaborations - Alliance with Wyeth continues for development of RNA for vaccine production

Dendritic Cell Vaccine - CD70 induction on dendritic cells promotes CD8+ T cell responses

Drug Development - Study shows cisplatan treatment unhindered by drug for drug-induced hearing loss

Equine Infectious Anemia Virus - Specificity of antibodies induced by equine infectious anemia virus reported

Finance - Biotech company receives going concern qualification in FY2004 audit report

Finance - Biotechnology company announces 2004 year-end financial results

Finance - Genetics-focused company reports fourth quarter, year end 2004 financial results

HIV/AIDS Prevention - Manufacturing company wins government tender for rapid HIV test in China

HIV/AIDS Screening - Molecular diagnostics company reports detection of HIV-DNA AIDS patients' urine

HIV/AIDS Therapy - Encouraging results reported from phase 2 trial of HIV immune-based therapy

HIV/AIDS Therapy - Legal order allows challenge to AIDS drug pricing in South African to go forward

HIV/AIDS Vaccine - Anti-CXCR4 antibodies differ significantly in ability to inhibit HIV entry

HIV/AIDS Vaccine - C-terminal tail of HIV transmembrane glycoprotein involved in cell fusion

HIV/AIDS Vaccine - HIV preventive vaccine trials in developing countries examined

HIV/AIDS Vaccine - Peptide immunogens enhance immune response against HIV mutant strains

HIV/AIDS Vaccine - Poxvirus SIV vaccine partially protects juvenile macaques against SIV

HIV/AIDS Vaccine - Predictive value of primate models for AIDS therapies reviewed

HIV/AIDS Vaccine - Role of IL-7 in pathogenesis and treatment of HIV infection reviewed

HIV/AIDS Vaccine - Targeting CD4i epitope in HIV vaccine design explored

HIV/AIDS Vaccines - Researchers' findings advance HIV/AIDS vaccines research

Head and Neck Cancer - Dendritic cells mature in presence of tumor cells from head and neck cancer

Human Papillomavirus - Epitope specificity of vaccine-induced T cell response against HPV18 reported

Human Papillomavirus - New research targets men to study virus that causes cancer in women

Immunology - Data advance knowledge in immunology research

Immunotherapy - Study shows utility of small-molecule telomerase activators for HIV/AIDS therapy

Influenza - Biotech company to pursue accelerated approval process for influenza vaccine

Influenza - Pharmaceutical company launches new version of its pediatric influenza vaccine

Influenza Vaccine - Acidic polymerase epitope of influenza elicits potent antiviral response

Influenza Vaccine - Approaches to influenza prevention and treatment in travelers reviewed

Influenza Vaccine - Growth of attenuated influenza vaccine strains in cell lines achieved

Influenza Vaccine - Safety and immunogenicity of adenovirus-vectored influenza vaccines reviewed

Influenza Vaccines - Findings describe new data in influenza vaccines research

Kidney Cancer Vaccine - Vaccine elicits diverse CD8+ T-cell responses to renal cell cancer antigens

Leukemia Vaccine - Leukemia vaccines may benefit from immune responses against Wilms tumor WT1

Leukemia Vaccine - Natural killer cell receptor-expressing cells play role in leukemia therapy

Listeria Therapy - CpG oligodeoxynucleotides enhance neonatal resistance to Listeria

Liver Cancer - MAGE-A10- and SSX-2-specific CD8+ responses in liver cancer characterized

Lymphoma Vaccine - Tumor-specific antigen of murine T-lymphoma defined with monoclonal antibody

Malaria Vaccine - CD28 in T and B cell responses required for protection against malaria

Malaria Vaccine - Genetic approach to identify immunity targets in malaria parasites developed

Malaria Vaccine - Polymerized d-peptides used for immunizing animals against malaria

Malaria Vaccines - Recent findings illuminate research in malaria vaccines

Measles - Measles deaths in Africa dropped by nearly half over 5 years

Measles Vaccine - Impact of population decline on dynamics of measles in Italy explored

Melanoma Vaccine - Gene expression in melanoma metastases and daughter cell lines investigated

Melanoma Vaccine - Hypothesis to explain ability of BCG and vaccinia to treat melanoma presented

Melanoma Vaccine - Melanoma-associated antigen mimotope inhibits melanoma cell growth

Mergers & Acquisitions - Shareholders of pharmaceuticals companies approve merger

Mucosal Immunization - Studies describe new findings in mucosal immunization research

Myelodysplastic Syndrome - Immunobiologic therapies for myelodysplastic syndrome reviewed

Myeloma Vaccine - Anti-alpha 4 integrin monoclonal antibody inhibits multiple myeloma growth

Myocardial Infarction - Phase 1 myoblast cell transplantation study data presented at cardiology meeting

Ovarian Cancer - Peptides from HER-2/neu-overexpressing tumors induce antitumor responses

Patents - RNA interference-based therapeutics company granted patent

Pediatrics - Pediatric nurse group alerts parents to dangers of rotavirus infection

Personnel - Defense contractor hires consultant to develop stem cell research center grant

Personnel - Margaret A. Liu, MD, appointed to board of DNA-focused biosciences company

Pharmaceutical Research - Healthcare, biotech ompanies join forces to conduct cancer biomarker study

Polio Vaccines - Researchers' work adds to polio vaccines body of knowledge

Product Licensing - BN ImmunoTherapeutics inlicenses technology for breast cancer vaccine

Prostate Cancer - Earlier use of prostate cancer vaccines urged by Hopkins scientists

Prostate Cancer Vaccine - Dendritic cell vaccine rescues peripheral T cell tolerance in prostate cancer

Rotavirus Vaccine - Immunization with rotavirus virus-like particles elicits immune responses

Rotavirus Vaccines - Researchers detail new studies and findings in the area of rotavirus vaccines

SARS Vaccine - Two neutralizing regions on SARS spike glycoprotein identified

SARS Virus - Hamster is better model than mouse for therapy against SARS virus replication

Salmonellosis Vaccine -  Salmonella pathogenicity island trigger colitis

Salmonellosis Vaccine - Extracts from Salmonella Enteritidis protect against salmonellosis

Schistosomiasis Vaccine - Calpain found in penetration glands of Schistosoma japonicum cercariae

Smallpox Vaccine - Severe headaches common after smallpox vaccination

Stroke Therapy - Antibodies specific for myelin-associated glycoprotein are neuroprotective

Tuberculosis Vaccine - Fragmented M. tuberculosis cells increase efficacy of therapy against TB

Tuberculosis Vaccine - Plasmid DNA encoding mycobacterial hsp65 is effective treatment for TB

Tuberculosis Vaccine - Secretory protein ESAT-6 of Mycobacterium tuberculosis cloned

Tuberculosis Vaccine - Vaccination of possums with BCG reduces Mycobacterium bovis replication

Tuberculosis Vaccines - New findings in the area of tuberculosis vaccines detailed

Vaccine Development - Accomplishments noted in smallpox vaccine program

Vaccine Development - Clinical holds for vaccine INDs reviewed

Vaccine Development - Company expands work load in support of vaccine development

Vaccine Development - Nanoparticle-based immunization challenges hepatitis B virus infection

Vaccine Development - Proteome microarrays used to profile humoral immune response to infection

Vaccine Development - Vaccinia or BCG immunization of melanoma patients linked to better survival

Vaccine Vector - Vector with mutant neo gene selects stable clones expressing fusion protein

Wound Healing - CE mark awarded to sell chitoskin wound pad in European Union countries

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