Chagas Disease Vaccine
Oral immunization with Phytomonas serpens protects against Trypanosoma
Published in Vaccine Weekly, April 6th, 2005
"We have previously demonstrated that Phytomonas serpens, a tomato parasite, shares antigens with Trypanosoma cruzi, the protozoa that causes Chagas disease. These antigens are recognized by human sera and induce protective immunity in BALB/c mice. In the present study, inducible nitric oxide synthase (iNOS) knockout (KO) mice and C57BL/6 mice treated with the nitric oxide inhibitor, aminoguanidine (AG, 50 mg/kg) infected with T. cruzi, were used to demonstrate the role of nitric oxide (NO) to host protection against T. cruzi...
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Source: Vaccine Weekly (2005-04-06)
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