Vaccine Development
Scientists look at simian virus 40 potential for cancer vaccination
Published in Vaccine Weekly, April 13th, 2005
According to a study published in the journal Virology, "Simian virus 40 (SV40) contains an essential protein, large tumor antigen (Tag), which assists in viral replication and causes cell transformation and immortalization."
D.B. Lowe and colleagues reported, "Our laboratory has examined plasmid DNA, expressing SV40 Tag under two different promoters, for use in potential cancer vaccination strategies. One plasmid, pSV3-neo, failed to induce SV40 Tag antibody, produced a weak cell-mediated response, and only partial protection in murine experimental tumor challenge...
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Source: Vaccine Weekly (2005-04-13)
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