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Immunization

Researchers plan strategy to defend neonates against encapsulated bacteria

Published in Vaccine Weekly, April 13th, 2005

Researchers plan to combine maternal and neonatal immunization to protect neonates against encapsulated bacteria.

According to a study from Iceland, "Maternal antibodies (MatAbs) may protect the offspring against infections but may also interfere with their immune responses to vaccination. We have previously shown that maternal immunization with pneumococcal polysaccharides (PPS) conjugated to tetanus protein (Pnc-TT) protected the offspring against infections caused by three important pediatric serotypes."

"To study the influence of MatAb on the immune response to Pnc-TT early in life, adult female mice were immunized twice with Pnc-TT of serotype 1...

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