Leukemia
HLA-G expression is linked with an unfavorable outcome in lymphocytic leukemia
Published in Vaccine Weekly, April 13th, 2005
According to a study from Germany, "The human leukocyte antigen G (HLA-G) molecule exhibits limited tissue distribution and exerts multiple immunoregulatory functions. Recent studies indicate an ectopic up-regulation in tumor cells that may favor their escape from antitumor immune responses. The role of HLA-G in B-cell chronic lymphocytic leukemia (B-CLL) has not been defined."
H. Nuckel and associates explained, "HLA-G expression was studied retrospectively in circulating B-CLL cells from 47 patients by flow cytometry using the anti-HLA-E specific monoclonal...
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Source: Vaccine Weekly (2005-04-13)
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