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Tick-Borne Disease

Serine protease inhibitor shows promise as anti-tick vaccine

Published in Vaccine Weekly, April 20th, 2005

A serine protease inhibitor (Serpin) from Haemaphysalis longicornis shows promise as an anti-tick vaccine.

"The application of anti-tick vaccine has been shown to be the most promising alternative tick control strategy compared to the current use of acaricides that suffer from a number of limitations. The success of this strategy is dependent on the cloning, and characterization of tick molecules involved in the mediation of tick central physiological roles. Rapid amplification of the cDNA ends (RACE) and primers designed based on a conserved serpin amino acid motif (NAVYFKG) were used to clone a cDNA with high similarity in the reactive center loop (RCL) to...

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