Published in Vaccine Weekly, April 27th, 2005
"The Hsp90 molecular chaperone system is involved in the activation of an important set of cell regulatory proteins, including many whose dysregulation drives cancer. Recruitment of protein kinases to the Hsp90 system is mediated by the co-chaperone adapter Cdc37, an essential protein whose overexpression is itself, oncogenic. Current structural, biochemical and biological studies of Cdc37 are beginning to unravel the nature of its interactions with Hsp90 and protein kinase clients, and implicate it as a key permissive factor in cell transformation by dysregulated protein kinases,"...
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