Apoptosis
Bovine leukemia virus involved in induction and inhibition of apoptosis
Published in Vaccine Weekly, April 27th, 2005
According to recent research from Japan, "In a previous study, we identified an interesting mutant form of the Tax protein of bovine leukemia virus (BLV), designated D247G, that has an enhanced capacity to transactivate the long terminal repeat (LTR) of BLV and the cellular proto-oncogene c-fos when compared with wild-type Tax (wt-Tax). We demonstrate here that an infectious strain of BLV containing the mutant D247G form of Tax also differs in its capacity to modulate cell survival both positively and negatively."
"When peripheral blood mononuclear cells (PBMCs)...
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Source: Vaccine Weekly (2005-04-27)
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