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Leprosy Risk Factors

Genetics of immunity in leprosy reviewed

Published in Vaccine Weekly, April 27th, 2005

Scientists review the genetics of immunity in leprosy in a recent issue of Current Opinion in Immunology.

According to a study from France, "Leprosy is a chronic infectious disease caused by Mycobacterium leprae that affects an estimated 700,000 new individuals each year. A strong contribution of host genetics to susceptibility to leprosy has long been suggested to account for the considerable variability observed between individuals exposed to M. leprae."

"As there is no relevant animal model for human leprosy, forward genetics is the main strategy used to identify the genes and, consequently, the immunological pathways involved...

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