Lymphoma
APl2-MALT1 fusion protein implicated in t(11;18)(Q21;q21) MALT lymphoma
Published in Vaccine Weekly, April 27th, 2005
According to published research from Japan, "At least three distinct chromosomal translocations, t(11;18)(q21;q21), t(1;14)(p22;q32) and t(14;18)(q32;q21) involving the API2 (also known as c-IAP2)-MALT1 fusion protein, BCL10, and MALT1, respectively, have been implicated in the molecular pathogenesis of MALT lymphoma."
"Our findings showed that several variants of the API2-MALT1 fusion protein can occur in patients with t(11;18)(q21;q21), and that API2-MALT1 can potently enhance activation of nuclear factor (NF)-kappaB signaling, which...
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Source: Vaccine Weekly (2005-04-27)
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