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Vaccine Weekly

Susan Hasty, Publisher

Table of Contents . . . May 4th, 2005

Non-Subscriber - Summaries Only

Related Areas: Other Issues in Vaccine Weekly | Other Publications

Influenza Vaccine - Double-stranded RNA poly(I:C) enhances influenza vaccine protection

Tuberculosis Vaccine -  Mycobacterium tuberculosis proteomes analyzed for vaccine epitopes

Tuberculosis Vaccine - Nasal boost improves primary BCG-induced protection against TB

Vaccine Development - Single-stranded RNA that stimulates CD14+CD11c+ monocytes identified

AIDS Research - Initiating ART in primary SIV may lead to mucosal immune system restoration

Adenovirus - Interaction of adenovirus protein with packaging sequences examined

Anticancer Therapy - Inhibitory effects of anticancer peptide from Mercenaria examined

Antitumor Activity - Antitumor activity of an ethanol extract of Nigella sativa seeds

Antivenom - Equine monovalent and polyvalent snake antivenoms compared

Apoptosis - Apoptosis in neutrophils studied, role of protein phosphatase 2A defined

HIV/AIDS Vaccines - Reports add new data to HIV/AIDS vaccines research

Apoptosis - E1A activated transcription of p73 and Noxa to induce apoptosis

Apoptosis - Effect of antineoplastic ether lipid compared with homologous compounds

Apoptosis - Impact of FASL-induced apoptosis on the elimination of tumor cells by NK cells

Apoptosis - Stearoyl-CoA desaturase protein and activity levels associated with apoptosis

Apoptosis - Tbx3 expression related to apoptosis and cell proliferation in rat bladder

Autoimmune Disease - Immune disease-focused biopharm company acquires assets for monoclonal antibody

Malaria Vaccines - Recent studies add new data to malaria vaccines research

Biological Therapy - Transfected B cells defeat problems linked to dendritic cell-related therapy

Birth Defects - DLC-1 deemed essential for embryonic development

Bovine Viral Diarrhea Virus - Cellular insertion in NS2 gene of BVDV is potential pathogenic marker

Breast Cancer - Conjugated linoleic acid reduced murine mammary tumor cell

Breast Cancer - New treatment developed for BRCA1/2-associated disease

Breast Cancer - PEA3 and AP-1 involved in regulation of breast cancer-linked gene, mammaglobin

Malaria Vaccines - Researchers describe findings in malaria vaccines studies

Brucellosis - Researcher reviews brucellosis at dawn of the 21st century

Business & Finance - Drug company concludes credit agreements to refinance Aventis acquisition

Business Update - Company focused on HIV prevention receives grant for product development

Business Update - Genetronics announces name change

Business Update - Influenza-focused drug company awarded $97 million U.S. HHS vaccine contract

Business Update - Microbial identification system meets U.S. FDA good manufacturing practices

Malaria Vaccines - Researchers provide details of new studies and findings in the area of malaria vaccines

COX-2 - Skin tumors studied, role of kinases clarified

Cancer Therapy - Personalized melanoma vaccine trial commences

Cancer Vaccine - Hypothetical proteins detected in 10 individual human tumor cell lines

Cancer Vaccine - Modification of tumor antigen induced divergent T lymphocyte responses

Cancer Vaccine - Monoclonal antibody fused to GM-CSF breaks tolerance to CEA

Cancer Vaccines - MHC epitope presentation by cancer vaccines is transporter-independent

Melanoma Vaccines - Studies advance knowledge in melanoma vaccines research

Cancer Vaccines - New findings in the area of cancer vaccines detailed

Cervical Cancer - p27(Kip1) downregulated telomerase activity in human cervical cancer

Childhood Immunization - Combination vaccine produces lower immune response

Clinical Trials - Phase I study of novel oral cancer compound, INCB7839, begins

Cryptococcus - MAT mating types of Cryptococcus neoformans stimulate B cells

Cytomegalovirus - Cytomegalovirus-specific CTLs enhanced by recombinant virus

Pneumococcal Vaccines - Researchers' work adds to pneumococcal vaccines body of knowledge

DNA Research - Italian patent application filed on transrenal DNA technology to detect HIV, TB

Drug Development - Computer modeling allows vaccine design by computer

Drug Resistance - Targeting senescence pathways reversed drug resistance in cancer

Epirubicin - Effects of epirubicin on proliferation of Ehrlich ascites carcinoma cells

Finance - Respiratory-focused company reports year end results of near 100% net increase

Flavonoids - Flavonoids-induced apoptosis tied to inhibition of fatty acid synthase activity

Pneumococcal Vaccines - Studies add new findings to pneumococcal vaccines body of knowledge

Gangrene -  Clostridium perfringens alpha-toxin characterized

HIV/AIDS Pathogenesis - HIV-1 catalytic core domain residues important for HIV-1 replication/integration

HIV/AIDS Prevention - Foundation, J&J to initiate programs to prevent PMTCT of HIV in 7 countries

HIV/AIDS Therapy - UK government lauded for microbicide development support

HIV/AIDS Vaccine - CTL programming allows soluble antigen to generate secondary CTL

HIV/AIDS Vaccine - Data on DNA-binding protein to correct human genes published online in 'Nature'

Tuberculosis Vaccines - Researchers' findings advance tuberculosis vaccines research

HIV/AIDS Vaccine - HLA peptide processing by dendritic cells from HIV+ patients examined

HIV/AIDS Vaccine - Immune-based biopharmaceutical company auditors note going-concern qualification

HIV/AIDS Vaccine - Segments of consecutive AA residues of HIV gp120 proposed as vaccine candidates

HIV/AIDS Vaccine - Vaccine-elicited antibodies reduce viremia in SIV-challenged macaques

HIV/AIDS Vaccines - Findings advance knowledge in HIV/AIDS vaccines research

Hematology - New findings in hematology described

Hepatitis B Vaccine - Immune response to hepatitis B DNA vaccine improves upon protein boosting

Hepatitis E Virus - Interactions involved in assembly of hepatitis E virus capsid analyzed

Herpesvirus Vaccine - Genital herpes protection linked to vagina-associated lymphoid tissue

Herpesvirus Vaccines - Recent findings in herpesvirus vaccines provide new insights

Human Papillomavirus - Investigational HPV vaccine reduced infection and disease in study

Human Papillomavirus - Papillomavirus virus-like particles activate Langerhans cells

Human Papillomavirus Vaccines - Researchers publish new studies and findings in the area of human papillomavirus vaccines

Immunology - Natural killer cells examined, control of adaptive immune responses defined

Influenza Vaccine - Company's cell-culture technology to be part of U.S. flu vaccine program

Influenza Vaccine - U.S. HHS awards $97M contract to develop cell-culture-based influenza vaccine

Kidney Cancer - von Hippel-Lindau (VHL) tumor suppressor protein sensitized cancer to bortezomib

Legal Issues - Gen-Probe prevails in arbitration concerning viral diagnostics collaboration

Leishmaniasis Vaccine -  Leishmania chagasi proteinase developed to diagnosis leishmaniasis

Leishmaniasis Vaccine - IL-9 is a susceptibility factor in Leishmania major infection

Leukemia - Pomolic acid triggered mitochondria-dependent apoptotic cell death in leukemia

Liver Damage - Contrasting effects of telomere shortening explored

Lung Cancer - Sulindac enhances adenoviral vector-mediated apoptosis in lung cancer

Malaria Vaccine - Antibody response to Plasmodium vivax apical membrane antigen reported

Malaria Vaccine - Spleen important in malaria

Malaria Vaccines - Recent findings illuminate research in malaria vaccines

Measles Vaccine - Measles-specific cytokine response after measles vaccinations reported

Measles Virus - Measles virus rescued from cloned cDNA using SLAM-expressing cells

Melanoma - DSMB recommends discontinuation of Canvaxin phase III trial for melanoma

Melanoma - Eugenol caused melanoma growth suppression through inhibition of E2F1

Melanoma Vaccine - Anti-vaccine T cells increased after vaccination with MAGE-3 protein

Melanoma Vaccines - Findings advance knowledge in melanoma vaccines research

Meningitis Vaccines - Research add new data to meningitis vaccines body of knowledge

Nipah Virus - Extra-cellular domain of Nipah virus glycoprotein purified

Oncology - Alterations of pre-mRNA splicing in cancer analyzed

Paracoccidioidomycosis - Active formamidase of Paracoccidioides brasiliensis characterized

Parasitology - Actin-based motility of intracellular pathogens reviewed

Personnel - Former Fleishman-Hillard executive joins vaccine company

Personnel - Vaccines company announces addition to board of directors

Pneumococcal Vaccine - Pneumococcal antibodies require CD1 molecules and CD8+ cells

Pneumococcal Vaccines - Research add new data to pneumococcal vaccines body of knowledge

Polio Vaccine - Childhood mortality after oral polio immunization campaign reported

Prostate Cancer - Inhibition of IkappaB kinase activity promoted apoptosis in prostate cancer

Prostate Cancer - Phase I/II clinical trial begins in patients with recurrent prostate cancer

Protein Expression - Link between protein structure and solubility on expression discussed

Protein Kinase - Ilimaquinone studied, role on gap junctional communication defined

Protein Synthesis - eIF2 alpha phosphorylation and stress perception in CHO cells examined

Pseudopodia - Proteomic characterization of harvested pseudopodia reported

Rheumatic Fever - Myocardial tissue damage occurs in rabbits injected with streptococci

Rheumatology - Therapy and dosing for pediatric rheumatic disorders reviewed

SARS Virus - Recent findings in SARS virus described

Salmonella Vaccines - Research in salmonella vaccines provides new insights

Shigellosis - Tyrosine kinase signaling and effectors of Shigella invasion reviewed

Smallpox Vaccines - Researchers publish new studies and findings in the area of smallpox vaccines

Snow Mountain Virus - Immunity following Snow Mountain virus challenge examined

Streptococcus Vaccines - Reports add new data to streptococcus vaccines research

Theileriosis Vaccines - Recent studies add new data to theileriosis vaccines research

Tuberculosis Vaccine - Advancing TB vaccines to phase I clinical trials in U.S. outlined

Tuberculosis Vaccine - Control of human host immunity to mycobacteria reviewed

Tuberculosis Vaccine - Expanding BCG antigenic repertoire improves protection against TB

Tuberculosis Vaccine - TB vaccines for the world reviewed

Tuberculosis Vaccines - Researchers' data advance tuberculosis vaccines research

Vaccine Development - Antibodies adsorbed to aluminum adjuvants characterized

Vaccine Development - Hepatitis B virus capsid protein is a potent antigen carrier for vaccines

Vaccines Adjuvant - New findings in the area of vaccines adjuvant described

Vaccinia Virus Vaccine - Poxvirus-specific CD8+ CTL epitopes with distinct profiles identified

Virology - MyD88 expression required for cross-presentation of viral antigens

Virology - Sendai virus nucleocapsid-like particles generated in yeast

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