Measles Virus

Measles virus rescued from cloned cDNA using SLAM-expressing cells

Published in Vaccine Weekly, May 4th, 2005

Scientists have achieved efficient rescue of measles virus from cloned cDNA using SLAM-expressing Chinese hamster ovary cells.

According to a study from Japan, "We here report a highly efficient reverse genetics system for measles virus (MeV), using Chinese hamster ovary cells constitutively expressing a MeV receptor human signaling lymphocyte activation molecule (CHO/hSLAM cells). The recombinant vaccinia virus vTF7-3 that encodes the T7 RNA polymerase under the control of the early/late promoter was used in the system. Replication of vTF7-3 was highly restricted in CHO/hSLAM cells, but the virus could still drive the T7 promoter, allowing us to recover MeV from the...

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Source: Vaccine Weekly (2005-05-04)

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