Tumor Suppression

Cell type-specific tumor suppression by Ink4a and Arf in mouse gliomagenesis

Published in Vaccine Weekly, May 11th, 2005

Scientists examined cell type-specific tumor suppression by Ink4a and Arf in Kras-induced mouse gliomagenesis.

"Homozygous deletion of the INK4a-ARF locus is one of the most frequent mutations found in human glioblastoma. We have previously shown that combined Ink4a-Arf loss can increase tumor incidence in both glial progenitor cells and astrocytes during mouse gliomagenesis. Here we have investigated the separate contribution of loss of each of the tumor suppressor genes in glial progenitor cells and astrocytes in Akt+Kras-induced gliomagenesis," scientists in Sweden reported.

"We show that Arf is the major tumor suppressor gene in both cell types....

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Source: Vaccine Weekly (2005-05-11)

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