Tumor Suppression
Relationship of senescent cells, tumor suppression and organismal aging examined
Published in Vaccine Weekly, May 11th, 2005
"Cells from organisms with renewable tissues can permanently withdraw from the cell cycle in response to diverse stress, including dysfunctional telomeres, DNA damage, strong mitogenic signals, and disrupted chromatin. This response, termed cellular senescence, is controlled by the p53 and RB tumor suppressor proteins and constitutes a potent anticancer mechanism. Nonetheless, senescent cells acquire phenotypic changes that may contribute to aging and certain age-related diseases, including late-life cancer," scientists in the United States reported.
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Source: Vaccine Weekly (2005-05-11)
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