Melanoma Vaccine

Multi-peptide vaccine for melanoma

Published in Vaccine Weekly, May 11th, 2005

MAGE-Al-, MAGE-A10-, and gp100-derived peptides are immunogenic when combined with granulocyte-macrophage colony-stimulating factor and montanide ISA-51 adjuvant and administered as part of a multi-peptide vaccine for melanoma.

According to a study from the United States, "Twelve peptides derived from melanocyte differentiation proteins and cancer-testis antigens were combined and administered in a single mixture to patients with resected stage 1113, 111, or IV melanoma. Five of the 12 peptides included in this mixture had not previously been evaluated for their immunogenicity in vivo following vaccination. We report in this study that at least three of these five...

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Source: Vaccine Weekly (2005-05-11)

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