Salmonella Vaccines
Recent findings in salmonella vaccines provide new insights
Published in Vaccine Weekly, May 11th, 2005
Study 1: Salmonella pathogenicity island 2-mediated overexpression of chimeric SspH2 proteins simultaneously induces of antigen-specific CD4 and CD8 T cells.
"Salmonella enterica serovar Typhimurium employs two different type III secretion systems (TTSS) encoded within Salmonella pathogenicity islands 1 and 2 (SPI1 and SPI2) for targeting of effector proteins into the cytosol of eukaryotic cells during different stages of the infection cycle. The SPI1 TTSS translocates virulence factors across the plasma membrane when the bacterium...
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Source: Vaccine Weekly (2005-05-11)
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