Published in Vaccine Weekly, May 18th, 2005
"The pathology of Alzheimer's disease (AD) shows a significant correlation between beta-amyloid peptide (beta AP) deposition and the clinical severity of dementia. The ability of site-directed antibodies towards the N-terminal region of beta-amyloid peptide to suppress in vitro formation of toxic beta-amyloid serves as a factual basis for in vivo investigations. We localized the epitope of these anti-aggregating antibodies, and injection of phage displaying this epitope induced antibodies against the whole anti-beta-amyloid peptide,"...
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