Cholangiocarcinoma

TNF-alpha promotes cholangiocarcinoma invasiveness via its receptor

Published in Vaccine Weekly, May 25th, 2005

Tumor necrosis factor (TNF) alpha promotes invasiveness of cholangiocarcinoma cells via its receptor, TNFR2.

"We studied the effect of TNF-alpha stimulation on a cholangiocarcinoma cell line, CCKS1. CCKS1 expressed only one type TNF receptor, TNFR2. Treatment of CCKS1 with TNF-a substantially activated NF kappa B, MAPK, and Akt signaling, which in turn activated matrix metalloproteinase-9 (MMP-9) secretion and in vitro invasiveness of CCKS1," scientists writing in the journal Cancer Letters report.

"Pretreatment of cells with anti-TNFR2 neutralizing antibody inhibited the TNF-alpha-dependent signaling and MMP-9 secretion and subsequently...

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Source: Vaccine Weekly (2005-05-25)

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