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Vaccine Weekly

Susan Hasty, Publisher

Table of Contents . . . June 1st, 2005

Non-Subscriber - Summaries Only

Related Areas: Other Issues in Vaccine Weekly | Other Publications

Cancer Vaccines - Programming hematopoietic stem cells provides long-term T cell immunity

Cancer Vaccines - Tumor proteome suppressed by an adenovirus-based skin patch vaccine

HIV/AIDS Vaccines - Safety of HeLa-based cell substrates in HIV vaccine reported

Pneumonic Plague Vaccine -  Yersinia pestis protein epitopes recognized by CD4 T cells reported

Smallpox Vaccine - Structure of poxvirus L1 protein elucidated

Adenovirus - Company introduces upgraded version of kit for adenovirus purification

Adenovirus - New findings in the area of adenovirus detailed

Adverse Drug Reaction - FDA to change regulations regarding side-effect information in drug ads

Alzheimer Disease - Prospects for disease-modifying therapy of Alzheimer disease outlined

Amyotrophic Lateral Sclerosis - FDA grants orphan-drug status to small-molecule drug candidate arimoclomol

Apoptosis - Citrus limonoids induced apoptosis in human neuroblastoma cells

Cancer Vaccines - New research in the area of cancer vaccines detailed

Asthma Pathogenesis - Transfer of T-helper cell clones attenuates asthmatic phenotype

Avian Influenza - Politicians bury their heads in the sand while global flu threat mounts

Awards - Charles Farthing receives 2005 HIV Leadership Award as 'outstanding physician'

Awards - Filtration device company nominated for award for aiding Indian vaccine makers

Awards - U.S. Army research group awards $4.09 million for development of malaria vaccine

Bioterrorism - FDA approves Vaccinia immune globulin for some reactions to smallpox vaccine

Breast Cancer - HIV Tat targeted into mitochondria of breast cancer cells

Breast Cancer - Imatinib mesylate monotherapy used to treat metastatic breast cancer

Breast Cancer - Melatonin-estrogen interactions related to breast cancer

Breast Cancer - Survey shows communication trends between cancer survivors and health providers

Business & Finance - Melanoma-focused pharmaceutical company reports Q1 2005 financial results

Business Update - Developer of biological products issues correction for computational error

Cancer Drugs - Manumycin A-induced apoptosis enhanced by methoxyamine in myeloid leukemia cells

Cancer Therapy - Antineoplastic potential of TNF discussed

Cancer Therapy - Continual progress in cancer research yields promising cancer therapies

Cancer Therapy - Skin cancer treatments focus on surgical approaches, new noninvasive therapies

Cancer Therapy - Studies describe new findings in cancer therapy research

Cancer Vaccines - Cancer immunotherapy targets minor histocompatibility antigens

Cancer Vaccines - Dendritic-cell-based therapeutic vaccination against cancer reviewed

Cancer Vaccines - Migration of dendritic-cell-based cancer vaccines reviewed

Cancer Vaccines - Native blood dendritic cells possess tumoricidal potential

Cancer Vaccines - New findings in the area of cancer vaccines detailed

Cancer Vaccines - Role of CD4+ cells and antibodies in breast cancer protection described

Cancer Vaccines - Support for immunological mechanism of cancer vaccines research published

Chagas Disease -  Trypanosoma cruzi-infected patients have varied antibody responses

Chickenpox Vaccine - Failure to get catch-up vaccinations causes varicella outbreak

Childhood Immunization - Parents who don't vaccinate their children may believe vaccines cause harm

Chlamydial Infections - Genome sequencing for Chlamydophila abortus may help curb infections

Colon Cancer - IL-8 promotes cell proliferation in human colon carcinoma cells

DNA Vaccines - Researchers describe findings in DNA vaccines studies

DPT Vaccines - Studies advance knowledge in DPT vaccines research

Drug Development - Fragile U.S. vaccine system needs improvement despite dramatic gains in health

Drug Development - Is the vaccine industry ailing?

Drug Development - New study compares influenza vaccine schedules in children

Ebola Vaccine - CD8-mediated protection against Ebola infection is perforin dependent

Ebola Vaccine - Single-shot outbreak vaccine provides protection against 'Ebola' in animal study

Emphysema - Animal model of autoimmune emphysema presented

Endotoxemia - Phospholipid emulsion neutralizes endotoxin in healthy volunteers

Epstein-Barr Virus - EBI3 may have role in regulating antiviral or antitumoral immune response

Finance - Biopharma reports Q1 net loss of $9.7 million

Finance - Biotech company focused on infectious disease, cancer reports Q1 2005 results

Finance - Monoclonal antibody-focused biotechnology company reports Q1 2005 results

Finance - NIAID awards first $27 million using new bioshield authorities

Foot and Mouth Disease - Immune response against peptides from foot-and-mouth disease analyzed

Foot and Mouth Disease - Inhibitory potential of RNAs against foot-and-mouth disease evaluated

Gastric Cancer -  H. pylori+enhanced mucosal IL-1beta production increases gastric cancer risk

Gastroenterology - Cases of early-stage carcinoids of the gastrointestinal tract analyzed

Gastroenterology - Gastrointestinal stromal tumor treated with imatinib

Gene Expression - Octamer/Sox elements required for cis regulation of Nanog gene expression

Group B Streptococcus - Structure of group B Streptococcus capsular polysaccharide determined

HIV/AIDS Pathogenesis - Each genomic RNA in HIV-1 heterozygous virus generate new virions

HIV/AIDS Pathogenesis - Single amino acid substitution controls HIV-1 Vif-dependent blocking of APOBEC3G

HIV/AIDS Research - EcoHIV murine model used to study systemic HIV-1 infection

HIV/AIDS Research - New pharmacokinetic data on taking Lexiva with Nexium released

HIV/AIDS Vaccine Development - Carbohydrate antigens targeted in HIV vaccine development

HIV/AIDS Vaccines - Business response to AIDS group selected to provide focal point for fund

HIV/AIDS Vaccines - New findings in HIV/AIDS vaccines described

HIV/AIDS Vaccines - Phase 1 trial of gene therapy treatment for HIV, plan for phase 2 study reported

Healthcare Coverage - Americans willing to pay more for greater vaccine coverage

Healthcare Coverage - Insurance company introduces health portfolio

Hepatitis B Vaccine - HBsAg-HBIG complex vaccine elicits potent anti-hepatitis immune response

Human Papillomavirus - High-risk mucosal HPV infections during infancy and childhood reviewed

Human Papillomavirus - Immune control of HPV-associated anogenital disease reviewed

Immunology - Deletion of antigen-specific T cells leads to long-term tolerance

Immunology - Lymphocyte subsets in infants analyzed by flow cytometry

Immunology - New findings in the area of immunology described

Influenza - Pediatric clinical study of needle-free flu vaccine delivery device underway

Influenza Epidemiology - Influenza in travelers to tropical and subtropical countries determined

Influenza Vaccine - Influenza vaccinations would benefit university students

Influenza Vaccine - Some evidence of link between neuroticism and antibody response found

Influenza Vaccine - Vaccination strategies for pandemic influenza optimized

Influenza Vaccines - Researchers publish new studies and findings in the area of influenza vaccines

Influenza Virus - Reappearance of influenza B/Victoria/2/87-lineage viruses reported

Information Technology - HIV-products developer re-launches website with expanded investor information

Legal Issues - Court dismisses class-action suit against vaccine company

Lung Cancer - Expression of TARSH gene in MEFs senescence implicated in human lung cancer

Malaria - Prostaglandin E-2 production impaired in children with cerebral malaria

Malaria - Research in malaria provides new insights

Malaria Prevention - 10 years before malaria vaccine is ready for widespread use

Measles Vaccines - Researchers report details of new studies and findings in the area of measles vaccines

Melanoma Vaccine - Stat3 activity in melanoma cells affects NO-mediated antitumor effects

Meningitis B Vaccine - Companies form collaboration to pursue research for meningitis B vaccine

Meningitis Vaccine - Variation reported in meningococcal PorA outer membrane protein

Mergers & Acquisitions - Cancer product development company completes acquisition of DELEX

Mergers & Acquisitions - Company to be acquired by GSK; shareholders get $4.40 per share in cash

Mergers & Acquisitions - GlaxoSmithKline announces acquisition

Monoclonal Antibodies - Number of BAT/CD3 cells appear to vary by cancer type

Mycobacterium Tuberculosis - MTB ESAT-6 gene products modify mycobacteria and immune system interaction

Mycobacterium Tuberculosis - Molecular basis of nitric oxide detoxification mechanism in MTB investigated

Neurofibromatosis - NF2 gene mutation detected in 100% of inherited cases via multiple techniques

Oncology - Researchers report details of new studies and findings in the area of oncology

Ovarian Cancer - Increase in antibodies to MUC1 associated with reduced cancer risk

Pediatric Vaccines - Pediatric immunization rates linked to physician reimbursement levels

Personnel - Henk Kocken, PhD, named VP for quality systems by biopharmaceutical company

Personnel - Zbigniew Wlwszek, PhD, appointed chief scientific officer of biotech company

Pertussis - Boarding school outbreak of pertussis in adolescents reported

Pertussis - FDA approves Boostrix, a new U.S. vaccine for adolescents against pertussis

Pneumococcal Vaccine - Pneumococcal vaccination effective for elderly people in Spain

Pneumococcal Vaccine - Vaccine does not induce lasting IgA response against otitis media

Pneumonia Vaccine - Pneumococcal and influenza vaccines effective for preventing pneumonia

Prostate Cancer - Pharmacokinetics of isotope-labeled antibody specific for PSA reported

Prostate Cancer - Secondary ellagic acid therapy in HRPC patients on standard chemotherapy tested

Quality Assurance - New consensus ambulatory performance measures established by collaborative group

Respiratory Syncytial Virus - RSV prevention can be guided by web-based early warning system

Shingles - Pharmaceutical co. submits biologics license application for shingles vaccine

Skin Cancer - Low-dose retinoids prevented cutaneous SCC in organ transplant recipients

Stem Cell Research - Antigen encounter at stem cell transplantation enhances T-cell response

Stem Cell Transplantion - Guide for vaccination of stem cell transplant recipients released

Streptococcus Vaccine -  Streptococcus gordonii strain shows promise as vaccine

Streptococcus Vaccine - Role of TNF during infection with Streptococcus pneumoniae reviewed

Tuberculosis Vaccine - Successful TB vaccines need to be immunoregulatory rather than Th1-boosting

Tuberculous Meningitis - BCG protects against tuberculous meningitis in Indian children

Tularemia Vaccine - Efficacy of live attenuated tularemia vaccine evaluated

Tumor Suppression - AP-1 dimers regulated transcription of p14/p19(ARF) tumor suppressor gene

Tumorigenesis - DNA damage response used as anti-cancer barrier in early human tumorigenesis

Tumorigenesis - Hematopoietic cells regulate angiogenic switch during tumorigenesis

Vaccines Adjuvant - Findings in vaccines adjuvant provide new insights

Virology - Reports describe recent advances in virology research

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