Cancer Vaccines

Tumor proteome suppressed by an adenovirus-based skin patch vaccine

Published in Vaccine Weekly, June 1st, 2005

A differential proteome in tumors was suppressed by an adenovirus-based skin patch vaccine encoding human carcinoembryonic antigen.

According to a study from the United States, "We created an anti-tumor vaccine by using adenovirus as a vector which contains a cytomegalovirus early promoter-directed human carcinoembryonic antigen gene (AdCMV-hCEA). In an attempt to develop the skin patch vaccine, we epicutaneously vaccinated BALB/c mice with AdCMV-hCEA. After 9 weeks post-immunization, vaccinated mice evoked a robust antibody titer to CEA and demonstrated the capability of suppressing in vivo growth of implanted murine mammary adenocarcinoma cell line (JC-hCEA) tumor...

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Source: Vaccine Weekly (2005-06-01)

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