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Cytomegalovirus

Cytomegalovirus studied, nature of post-transplantation protection defined

Published in Vaccine Weekly, June 8th, 2005

According to recent research from Germany published in the Journal of Experimental Medicine, protection from cytomegalovirus (CMV) after transplantation is correlated with immediate early 1-specific CD8 T cells

"T cells are crucial for the control of CMV in infected individuals. Although CMV-specific T cells can be quantified by various methods, clear correlates of protection from CMV disease have not been defined. However, responses to the pp65 protein are believed to play an important role," wrote T. Bunde and colleagues, University of Medicine Berlin.

"Here, the proportions of interferon gamma-producing T cells following ex vivo activation...

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