Lung Cancer
DBC1 suggested as tumor suppressor in non-small cell lung cancers
Published in Vaccine Weekly, June 15th, 2005
According to recent research from Japan, "Genome-wide screening of DNA copy number aberrations in 27 cell lines derived from NSCLCs, using a custom-made comparative genomic hybridization (CGH)-array, identified a homozygous deletion of the DBC1 in one cell line. Homozygous deletion of DBC1, located at 9q33.1, was also observed in two of 53 primary NSCLC tumors examined."
"Moreover, 21 of the other 26 cell lines showed complete loss of DBC1 expression, although normal lung tissues express this gene, and...
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Source: Vaccine Weekly (2005-06-15)
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