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Vaccine Weekly

Susan Hasty, Publisher

Table of Contents . . . June 22nd, 2005

Non-Subscriber - Summaries Only

Related Areas: Other Issues in Vaccine Weekly | Other Publications

Dengue Fever - Dengue virus vaccine induces broad protective antibody response

Liposomal Delivery - Vaccine delivery in transfersomes, niosomes and liposomes compared

Parkinson Disease - Delayed gene therapy is efficacious in rat model of Parkinson disease

Smallpox Vaccine - Interferon peptide mimetics possess antiviral properties

Varicella Zoster Virus - Varicella-zoster vaccine before transplant protects against infection

Acute Myeloid Leukemia - Wnt/beta-catenin pathway involved in acute myeloid leukemia pathogenesis

Allergy Medicine - New allergen exposure exerts adjuvant effect on first allergen

Alzheimer Disease - Researchers detail new studies and findings in the area of Alzheimer disease

Amyotrophic Lateral Sclerosis - Company files IND application for arimoclomol to treat ALS

Anthrax Vaccines - Reports advance knowledge in anthrax vaccines research

Antioxidants - Efficacy of tamoxifen augmented rat breast tumorigenesis

Cancer Therapy - Reports add new data to cancer therapy research

Awards - Future doctors honored for advancing equal care

Baculovirus Vaccine - SARS coronavirus protein possesses interesting structure

Biological Therapy - Understanding tumor suppressive mechanisms of SCs may lead to cancer therapies

Breast Cancer - High efficacy and low toxicity of weekly docetaxel treated breast cancer

Breast Cancer - New data confirm early start of anastrozole may prevent breast cancer recurrence

Business & Finance - Biotechnology company completes round of $18.36 million private placement

Cancer Vaccines - Reports describe recent advances in cancer vaccines research

Business Update - Diagnostics company opens east Africa sales office

Cancer Therapy - Oral compound may replace intravenous chemotherapy after surgery, data show

Cancer Therapy - Recent findings illuminate research in cancer therapy

Cancer Therapy - p53 cancer vaccine sensitizes tumors to platinum, taxane chemotherapies

Cancer Vaccines - Reports advance knowledge in cancer vaccines research

Liver Cancer - Studies add new findings to liver cancer body of knowledge

Chagas Disease - Studies add new findings to Chagas disease body of knowledge

Chemotherapies - Docetaxel and celecoxib inhibited non-small cell lung cancer

Chronic Myelogenous Leukemia - CML progenitor cells identified with hemangioblastic characteristics

Clinical Trials - Antimetastatic activity of novel mechanism-based gelatinase inhibitor explored

Collaborations - Biopharmaceuticals company announces research collaboration with Biogen Idec

Pneumococcal Vaccines - New findings in the area of pneumococcal vaccines described

Collaborations - Deal signed with University of Massachusetts for Chlamydia vaccine

DNA Vaccine - Nuclear transfer of plasmid DNA condensed with protamine evaluated

DNA Vaccine - Penetratin enhances polymethacrylate-mediated gene delivery

Dendritic Cell Vaccine - Antigen loaded on heat shock protein elicits scant CD8 activation

Dengue Fever - Early T-cell responses to dengue virus epitopes described

Diagnostics - VSCAN HIV 1&2 and TB tests gain regulatory approval in the Ukraine

Vaccines Development - New research in the area of vaccines development detailed

Diarrhea - New approaches to treat bacterial and protozoal infections reviewed

Drug Delivery - Preclinical results with transdermal drug technology announced

Drug Development - IGN101 reduces disseminating tumor cells in patients with epithelial cancers

Drug Development - Positive data reported from phase II trial of GVAX vaccine for leukemia

Drug Development - Scientists demonstrate new way of fighting antibiotic resistance

Encephalitis Vaccine - Cytokine-encoding plasmid delivery improves immune response

Finance - Diagnostic technology company announces $1.2 million funding commitment

Flavonoids - Dietary bioflavonoids induced apoptosis in human leukemia cells

Gastroenterology - Reports advance knowledge in gastroenterology research

HDAC Inhibitors - Novel HDAC inhibitors with radiosensitizing properties

HIV/AIDS Vaccine - Company obtains HIV vaccine license from NIH

HIV/AIDS Vaccine - Dendritic cell vaccine aids patients with chronic HIV-1 infection

HIV/AIDS Vaccine - Detection of HIV gag- and pol-CD8/A2 help monitor vaccine efficacy

HIV/AIDS Vaccine - HIV-mediated cell fusion differentially inhibited by C34 peptides

HIV/AIDS Vaccines - Researchers publish new studies and findings in the area of HIV/AIDS vaccines

Heart Transplant - Glycosyltransferase genes induced histoblood group A antigen expression

Hepatomas - Inhibition of mTOR suppressed experimental liver tumors

Herpes Simplex Virus - Herpesvirus designed to enter malignant glioma cells characterized

Herpes Vaccine - Herpesvirus glycoprotein DNA vaccine induces cytotoxic T-lymphocytes

Herpes Vaccine - Method to predict effects of imperfect herpes vaccines developed

Immunology - B cells prime naive CD4+ T cells without other antigen-presenting cells

Immunology - Vaccine induces CD4/CD8 double-positive non-specific suppressor T cells

Immunotherapy - New immunization recommendations issued for meningococcal disease

Influenza Vaccine - BLA submitted for Fluarix

Influenza Vaccine - Polycation-mediated delivery of siRNAs prevent influenza infection

Influenza Vaccine - Sequence comparison of influenza A viruses aids vaccine design

Influenza Vaccines - Studies add new findings to influenza vaccines body of knowledge

Liver Cancer - Researchers' data advance liver cancer research

Malaria Vaccines - New findings in malaria vaccines described

Melanoma - Vaccine targets tumors where they live

Melanoma Vaccine - Peptide vaccine induces prolonged relapse-free interval in melanoma

Melanoma Vaccines - New findings in the area of melanoma vaccines detailed

Meningitis - Association supports meningococcal disease vaccination for youth

Meningitis Vaccine - Vaccine strategies for meningococcal disease in travelers outlined

Motexafin Gadolinium - Motexafin gadolinium disrupted zinc metabolism in human cancer cell lines

Neurology - Scorpion neurotoxin cloned, potassium channel-blocking activity reported

Oncology - Antiangiogenic immunotherapy targets signals that fortify cancer growth

Paclitaxel - In vitro interaction between paclitaxel and oxaliplatin examined

Pancreatic Beta Cells - Efficient restricted gene expression in beta cells reported

Pancreatic Cancer - Findings on immunotherapy anticancer drug for pancreatic cancer published

Parkinson Disease - Gene transfer of decarboxylase protects striatal cultures from L-DOPA

Patents - New patent covers approach to increase carrying capacity of AAV vectors

Personnel - Douglas Beck named CFO of inflammatory disease-focused biopharmaceutical company

Personnel - Steven J. Mento appointed to board of directors by DNA-focused research company

Pneumococcal Vaccine - Mucosal immunization promotes polysaccharide-specific memory responses

Pneumococcal Vaccine - Vaccine reduce pneumonia in HIV-infected and -uninfected children

Pneumococcal Vaccines - New findings in pneumococcal vaccines described

Pulmonary Medicine - Influenza vaccination reduces severity of COPD

Respiratory Medicine - Studies add new findings to respiratory medicine body of knowledge

Rotavirus Infection - Method to detect memory T-cell response to rotavirus developed

Rotavirus Vaccines - Researchers' findings advance rotavirus vaccines research

SARS Therapy - Protein-based SARS-CoV entry inhibitors developed

Schistosomiasis Vaccine - Epitopes of Schistosoma fatty acid-binding protein mapped

Smallpox Vaccines - Findings in smallpox vaccines provide new insights

Streptococcus Vaccine - Immune response to laminin-binding protein in infection described

Travel Medicine - Vaccine-preventable diseases in long-term expatriates reviewed

Tuberculosis Vaccine - Gamma/delta T-lymphocyte activity against M. bovis analyzed

Tuberculosis Vaccines - New findings in tuberculosis vaccines described

Vaccine Policy - Exemptions to school immunization requirements discussed

Vaccine Safety - System to detect early signs of adverse vaccine events developed

Vaccine Vector - Best vector systems for gene transduction into dendritic cells studied

Vaccine Vector - Lentivirus vector induces megakaryocyte-specific gene expression

Vaccine Vector - Single regulated lentiviral vectors compared to constitutive promoter

Vaccine Vector - Vector developed using bacterial artificial chromosome cloning

Vaccine Vector - Vectors and delivery systems in gene therapy reviewed

Vaccines Development - New findings in the area of vaccines development described

Vaccinia Virus - Isatin-beta-thiosemicarbazones as anti-poxvirus agents optimized

Vaccinia Virus - Therapeutic value of vaccinia-immune IgG investigated

Virology - Studies advance knowledge in virology research

Virology Vaccine - Vaccine strategies for chronic viral infections reviewed

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