Vaccinia Virus
Isatin-beta-thiosemicarbazones as anti-poxvirus agents optimized
Published in Vaccine Weekly, June 22nd, 2005
"Novel strategies are required to combat poxvirus infections, whether caused by escape of viruses such as monkeypox from indigenous areas or intentional release of smallpox. Anti-smallpox drugs with a unique mode of antiviral action, inhibition of transcription termination, were known but not therapeutically useful," scientists in the United States report.
"Using a combinatorial method, variants of the basic isatin-beta-thiosemicarbazone structure were prepared and examined for cytotoxicity and antiviral activity in vaccinia virus- and cowpox virus-infected human...
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Source: Vaccine Weekly (2005-06-22)
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