Dengue Fever

Dengue virus vaccine induces broad protective antibody response

Published in Vaccine Weekly, June 22nd, 2005

Recombinant, live-attenuated tetravalent dengue virus vaccine formulations induce a balanced, broad, and protective neutralizing antibody response against each of the four serotypes in rhesus monkeys.

"Three tetravalent vaccine (TV) formulations of previously described monovalent dengue (DEN) virus vaccine candidates were compared to a tetravalent formulation of wild-type DEN viruses (T-wt) for replication in SCID mice transplanted with human liver cells (SCID-HuH-7) or for replication and immunogenicity in rhesus monkeys. TV-1 consists of recombinant DENI, -2, -3, and -4, each with a 30-nucleotide deletion in the 3' untranslated region (Delta 30). TV-2 consists of...

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Source: Vaccine Weekly (2005-06-22)

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