Published in Vaccine Weekly, June 22nd, 2005
"Three tetravalent vaccine (TV) formulations of previously described monovalent dengue (DEN) virus vaccine candidates were compared to a tetravalent formulation of wild-type DEN viruses (T-wt) for replication in SCID mice transplanted with human liver cells (SCID-HuH-7) or for replication and immunogenicity in rhesus monkeys. TV-1 consists of recombinant DENI, -2, -3, and -4, each with a 30-nucleotide deletion in the 3' untranslated region (Delta 30). TV-2 consists of...
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