Drug Development

Scientists demonstrate new way of fighting antibiotic resistance

Published in Vaccine Weekly, June 22nd, 2005

A team of scientists at The Scripps Research Institute and the University of Wisconsin have demonstrated a new way of fighting antibiotic resistance: by stopping evolution.

In the June issue of the open-access journal PloS Biology, the team describes how a protein called lexA in the bacterium Escherichia coli promotes mutations and helps the pathogen evolve resistance to antibiotics. The scientists also show that E. coli evolution could be halted by subjecting the bacteria to compounds that block lexA. Interfering with this protein renders the bacteria unable to evolve resistance to the common antibiotics ciprofloxacin and rifampicin.

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Source: Vaccine Weekly (2005-06-22)

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