Rotavirus Vaccines

Researchers' findings advance rotavirus vaccines research

Published in Vaccine Weekly, June 22nd, 2005

Investigators in the United States and New Zealand have published new rotavirus vaccines data.

Study 1: Skin immunization with rotavirus VP6 protein and the adjuvant LT(R192G) induced partial protection in mice.

"Oral or intranasal administration of mice with rotavirus VP6/LT(R192G) vaccine induces between 95 and 99% protection against fecal shedding of rotavirus after challenge. However, mucosal administration of LT(R192G) is controversial. Subcutaneous, intradermal or Biojector injection induced high titers of serum VP6-specific IgG, eliciting only partial to no protection (73, 0, and 26%, respectively), while transcutaneous delivery using gauze...

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Source: Vaccine Weekly (2005-06-22)

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