Vaccine Delivery
Directed cell migration achieved via chemoattractants from microspheres
Published in Vaccine Weekly, June 29th, 2005
"Chemotaxis, cell migration directed by spatial concentration gradients of chemoattractant molecules, is critical for proper function of the immune system.
"Materials capable of generating defined chemoattractant gradients via controlled release may be useful for the design of improved vaccines and immunotherapies that draw specific cells to an immunization site. To this end, we encapsulated formyl-Nle-Leu-Phe-Nle-Tyr-Lys (fN'LFN'YK) peptides or macrophage inflammatory protein-3 alpha (MIP-3 alpha or CCL20) in degradable...
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Source: Vaccine Weekly (2005-06-29)
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