Published in Vaccine Weekly, July 13th, 2005
"Agonistic antibodies against CD40 have great potential as immunological adjuvants. We have shown that CD40mAbs induce strong antibody responses against conjugated antigen, and that this enhancement of responses extends to any sequence physically associated to the CD40 binding moiety, including the antibody's own Fc region. Thus, the CD40mAb acts as a model immunogen, containing both antigenic (i.e., Fc portion) and CD40 binding motifs (i.e., CD40 binding moiety). Using this system we examine here whether CD40mAb is able to directly mimic T cell...
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