HIV/AIDS Vaccines
New research in the area of HIV/AIDS vaccines detailed
Published in Vaccine Weekly, July 13th, 2005
Study 1: An HIV-1 minimal gag protein is superior to nucleocapsid at in vitro tRNA3 Lys annealing and exhibits multimerization-induced inhibition of reverse transcription.
"HIV-1 uses tRNA3 Lys to prime reverse transcription of its viral RNA. In this process, the 3'-end of tRNA3 Lys must be annealed to the primer binding site of HIV-1 genomic RNA, and the two molecules together form a complex structure. During annealing, the nucleocapsid (NC) protein enhances the unwinding of tertiary structures...
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Source: Vaccine Weekly (2005-07-13)
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