Muscular Dystrophy
Gene transfer into skeletal muscle achieved using adenovirus serotypes
Published in Vaccine Weekly, July 13th, 2005
According to recent research from the United States, "Skeletal muscle is an interesting target for gene delivery because of its mass and because the vectors can be delivered in a noninvasive way. Adeno-associated virus (AAV) vectors are capable of transducing skeletal muscle fibers and achieving stable and safe transgene expression. To date, most animal experiments using AAV have been based on AAV serotype 2, but some recent studies have demonstrated that AAV1 is more efficient than AAV2/2 in transducing muscle fibers."
"Recently, novel AAVs (AAV7 and...
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Source: Vaccine Weekly (2005-07-13)
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