Cervical Cancer

HPV capsid mutation allows escape from cervical cancer immunity

Published in Vaccine Weekly, July 27th, 2005

A human papillomavirus (HPV) capsid mutation allows the escape from dendritic cell-dependent innate immunity in cervical cancer.

"Infection with oncogenic human papillomaviruses (HPVs), typified by HPV type 16 (HPV16), is a necessary cause of cervical cancer. Prophylactic vaccination with HPV16 L1 virus-like particles (VLPs) provides immunity. HPV16 VLPs activate dendritic cells and a potent neutralizing immunoglobulin G (IgG) response, yet many cervical cancer patients fail to generate detectable VLP-specific IgG.

"Therefore, we examined the role of the innate recognition of HPV16 L1 in VLP-induced immune responses and its evasion during...

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Source: Vaccine Weekly (2005-07-27)

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