Adriamycin Nephropathy
Naked DNA encoding MCP-1 and RANTES protects against renal injury
Published in Vaccine Weekly, July 27th, 2005
"We have previously shown that monocyte chemoattractant protein-1 (MCP-1) and regulated upon activation, normal T-cell expressed and secreted (RANTES) are significantly increased in renal cortex in adriamycin nephropathy," researchers in Australia report.
"In this study, we tested the effect of DNA vaccination encoding the C-C chemokines MCP-1 and RANTES in a rat model of adriamycin nephropathy. Both reverse transcription-polymerase chain reaction (RT-PCR) products of MCP-1 and RANTES used as constructs were cloned into a pTarget vector...
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Source: Vaccine Weekly (2005-07-27)
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