Published in Vaccine Weekly, July 27th, 2005
According to recent research from Sweden, "We show, for the first time, that the transcription factor T-bet, which is implicated in IFN-gamma production, is required for the induction of vaccine-induced antiviral immune protection. T-bet was found to be important in both the innate and acquired immune protection against genital HSV-2 infection. T-bet-/- and T-bet+/+ mice were infected vaginally with HSV-2 and examined daily for disease and mortality. T-bet-/- mice had significantly higher virus titers than T-bet+/+ mice following a...
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