Proteomics

Protein-protein inhibitors being developed

Published in Vaccine Weekly, August 3rd, 2005

Protein-protein inhibitors are being developed that can be used in cancer treatment.

According to a recent review from the United States, "There has been much progress in the discovery of small, organic molecules that inhibit protein-protein interactions, particularly in the field of cancer. Tubulin polymerization represents a classic target whose function can be allosterically modulated by small molecules."

"Several protein-protein complexes that regulate apoptosis, or programmed cell death, appear to be particularly amenable to inhibition by small molecules, and recently described compounds have helped to characterize Bcl-2, MDM2 and XIAP as drug...

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Source: Vaccine Weekly (2005-08-03)

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