Tularemia Vaccine

F. tularensis vaccine strain induces only human cells to secrete cytokines

Published in Vaccine Weekly, August 3rd, 2005

The live vaccine strain of Francisella tularensis replicates in human and murine macrophages but induces only the human cells to secrete proinflammatory cytokines.

"Francisella tularensis is the highly infections agent of tularemia, a disease that can prove fatal in humans. An attenuated live vaccine strain (LVS) of this bacterium is avirulent in man but produces lethal illness in mice. As a step toward understanding the species specificity of the LVS, we compared its interactions with murine and human leukocytes. The bacterium replicated within immune bone marrow-derived macrophages (muBMDM), human monocyte-derived macrophages (huMDM), and freshly...

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Source: Vaccine Weekly (2005-08-03)

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