HIV/AIDS Vaccines

New findings in the area of HIV/AIDS vaccines detailed

Published in Vaccine Weekly, August 3rd, 2005

Data on HIV/AIDS vaccines are outlined in reports from Canada, Italy and the United States.

Study 1: Conformational constraints imposed on a pan-neutralizing HIV-1 antibody epitope result in increased antigenicity but not neutralizing response.

"2F5 is one of the few broadly neutralizing monoclonal antibodies against type I human immunodeficiency virus (HIV-1). It recognizes the amino acid sequence ELDKWAS in gp41. We have previously identified a number of immunotargeting 2F5-reactive candidate immunogens. Three of them (designated H-BT1-3) have the ELDKWAS sequence constrained at beta-turn sites within the immunoglobulin heavy chain. Two others...

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Source: Vaccine Weekly (2005-08-03)

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