Apoptosis
Agonistic peptide targeting Fas molecule designed
Published in Vaccine Weekly, August 3rd, 2005
"A small agonistic peptide FRAP-4 (WEWT, Fas reactive peptide-4) that binds to the human Fas molecule was discovered using our computer screening strategy named the Amino acid Complement Wave (ACW) method, which is based on the complementarities of interacting amino acids between comprehensive testing peptides and a target protein surface pocket. In silico docking studies demonstrated the specific interaction of FRAP-4 with the main Fas ligand (FasL) binding domain in the Fas molecule," scientists in Japan reported.
"An octamer of this peptide produced by carboxyl terminal linkages of...
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Source: Vaccine Weekly (2005-08-03)
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