Published in Vaccine Weekly, August 10th, 2005
"Advances in gene transfer to the conducting airways for the treatment of pulmonary diseases such as cystic fibrosis have identified several vector classes that transduce airway epithelia in vitro and in animal models. One barrier to epithelial gene transfer is the rapid removal of materials from the airway surface via mucociliary clearance. This host defense mechanism limits gene transfer efficiency to airway epithelial cells," scientists in the United States report.
"Here we show that formulation of gene transfer vectors with viscoelastic gels provides longer...
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