Tuberculosis Vaccine

Combined DNA vaccines protect cattle from Mycobacterium bovis

Published in Vaccine Weekly, August 17th, 2005

Combined DNA vaccines formulated either in DDA or in saline protect cattle from Mycobacterium bovis infection.

According to recent research from China, "We tested the effectiveness of combined DNA vaccines encoding antigens Ag85B, MPT64, and MPT83 from Mycobacterium tuberculosis on cattle. Our results showed that calves treated with combined DNA vaccines in the presence of dimethyldioctyldecyl ammonium bromide (DDA) or saline elicited a strong gamma interferon (IFN-gamma) response 1 or 2 months after the third vaccination."

"All three antigens induced substantial levels of IFN-gamma production 1 month after the bacterial challenge, when...

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Source: Vaccine Weekly (2005-08-17)

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