Cocaine Vaccine

Glyceride adjuvant induces protective antibodies against cocaine

Published in Vaccine Weekly, August 17th, 2005

Intranasal immunization using a glyceride adjuvant induced protective and specific antibodies against cocaine.

According to a study from Iceland, "The goal of this study was to investigate an intranasal cocaine vaccine containing the mucosal adjuvant macrogol-6-glycerol capylocaprate (RhinoVax). Cocaine-KLH conjugate was prepared and administered in two formulations. Ten mice were immunized intranasally using RhinoVax as adjuvant and 10 subcutaneously using aluminum hydroxide as an adjuvant. A negative control group (n=10) received unconjugated KLH with RhinoVax intranasally."

"Specific cocaine antibodies in serum were measured following primary and...

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Source: Vaccine Weekly (2005-08-17)

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