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Nicotine Vaccine

Nicotine-specific antibodies reduce nicotine distribution to brain

Published in Vaccine Weekly, August 17th, 2005

Monoclonal nicotine-specific antibodies reduce nicotine distribution to the brain in rats.

According to a study from the United States, "Vaccination against nicotine is being studied as a potential treatment for nicotine dependence. Some of the limitations of vaccination, such as variability in antibody titer and affinity, might be overcome by instead using passive immunization with nicotine-specific monoclonal antibodies. The effects of antibodies on nicotine distribution to brain were studied using nicotine-specific monoclonal antibodies (NICmAbs) with Kd values ranging from 60 to 250 nM and a high-affinity polyclonal rabbit antiserum (Kd =1.6...

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