Tuberculosis Vaccine

Single M. tuberculosis antigen protects against tuberculosis

Published in Vaccine Weekly, August 17th, 2005

Immunization with a single Mycobacterium tuberculosis recombinant antigen, MTB41, protected mice and guinea pigs against tuberculosis.

According to a study from the United States, "MTB41 is a mycobacterium antigen that is recognized by CD4+ T cells early after experimental infection of mice with Mycobacterium tuberculosis and by PBMC from healthy PPD-positive individuals. Immunization of mice with plasmid DNA encoding the MTB41 gene sequence results in the development of antigen-specific CD4+ and CD8+ T cells, and protection against challenge with virulent M. tuberculosis."

"In the present studies, in contrast to DNA...

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Source: Vaccine Weekly (2005-08-17)

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